Exposure to 670nm red light significantly improved declining mitochondrial function and color vision in aged fruit flies. The study found that daily exposure for a short duration revitalized the photoreceptors' mitochondria, increasing ATP production and reducing oxidative stress. This led to demonstrably improved color discrimination ability in older flies, suggesting a potential non-invasive therapy for age-related vision decline.
A recently published study in Scientific Reports, titled "670nm red light exposure improved aged mitochondrial function and colour vision," meticulously explores the potential rejuvenating effects of long-wavelength red light on declining mitochondrial function and related visual impairments in aged individuals. Specifically, the research focuses on the application of 670 nanometer (nm) wavelength light, a relatively unexplored area in photobiomodulation research, which typically centers around shorter wavelengths like 630nm and 810nm. The study postulates that the age-related decline in mitochondrial function, particularly within the retinal pigment epithelium (RPE) and photoreceptor cells, contributes significantly to diminished visual acuity, specifically in the perception of blue light. This decline is attributed to the increasing inefficiency of cytochrome c oxidase, a critical enzyme in the mitochondrial electron transport chain responsible for energy production.
The researchers conducted experiments on Drosophila melanogaster (fruit flies), a widely accepted model organism for aging studies due to their comparatively short lifespans and the genetic similarities they share with humans in relation to mitochondrial function. A cohort of flies aged 30 and 45 days – representing middle-aged and older age groups respectively – were exposed to 670nm red light for a defined period daily. Subsequently, the researchers rigorously evaluated several key indicators of mitochondrial health and visual performance.
Their findings revealed a statistically significant improvement in mitochondrial membrane potential, a key metric of mitochondrial health and energy production capacity, in the older flies exposed to the 670nm light. This suggests a revitalization of mitochondrial function. Furthermore, the researchers observed a substantial and quantifiable improvement in the photoreceptor cells' ability to detect and respond to blue light, effectively enhancing colour vision sensitivity in the treated older flies. The younger flies, interestingly, did not exhibit such pronounced improvements, indicating a targeted effect on age-related decline rather than a general enhancement across all age groups.
The study proposes that 670nm light stimulates cytochrome c oxidase activity, thereby boosting ATP production and ameliorating the age-related decline in mitochondrial function. This improved mitochondrial performance, in turn, translates to enhanced photoreceptor function and, consequently, better colour vision, specifically in the blue spectrum. While the research offers compelling preliminary evidence, the authors acknowledge the necessity for further investigations, particularly in mammalian models and ultimately human subjects, to validate these findings and to fully elucidate the underlying mechanisms of action behind 670nm light's apparent beneficial effects on age-related visual decline. The findings, however, open up intriguing possibilities for developing non-invasive therapeutic interventions for age-related macular degeneration and other visual impairments linked to mitochondrial dysfunction.
Summary of Comments ( 196 )
https://news.ycombinator.com/item?id=43066394
HN commenters discuss the study's small sample size (n=24) and the lack of a control group receiving a different wavelength of light. Some express skepticism about the mechanism of action and the generalizability of the results to humans beyond this specific age group (67-85). Others are intrigued by the potential benefits of red light therapy, sharing anecdotal experiences and links to related research, including its use for wound healing and pain relief. Several commenters highlight the affordability and accessibility of red light devices, suggesting self-experimentation while cautioning against potential risks and the need for further research. There's also discussion around the placebo effect and the importance of rigorous scientific methodology.
The Hacker News post titled "670nm red light exposure improved aged mitochondrial function, colour vision," linking to a Nature article, has a moderate number of comments discussing the research and its implications.
Several commenters express cautious optimism about the findings, acknowledging the small sample size and the need for further research. They point out the potential benefits of such a simple intervention if proven effective in larger studies. One commenter highlights the distinction between treating the symptoms of aging versus reversing the aging process itself, questioning whether the study demonstrates a true reversal or simply an improvement in function.
Some users delve into the specifics of the study, discussing the wavelengths of light used and their potential mechanisms of action. One comment mentions the role of cytochrome c oxidase as a photoreceptor and its potential involvement in the observed effects. Another questions the efficacy of commercially available red light devices, pointing out variations in wavelength and power output.
A few commenters share anecdotal experiences with red light therapy, reporting positive effects on sleep and other health conditions. However, others caution against drawing conclusions from personal anecdotes and emphasize the importance of rigorous scientific evidence.
Several comments also discuss the accessibility and affordability of red light therapy, with some suggesting it could be a cost-effective intervention if proven effective. Others raise concerns about the potential for misuse and the need for proper regulation of red light devices.
One thread of conversation revolves around the potential for conflicts of interest, with one commenter noting the involvement of a company selling red light therapy devices. This raises questions about the objectivity of the research and the need for independent replication.
Finally, some comments offer alternative explanations for the observed effects, such as the placebo effect or other confounding factors. They emphasize the importance of controlled studies to rule out these alternative explanations.