A gene-edited banana variety, called the "Tropic," developed by scientists at Tropic Biosciences and Norwich University, could significantly reduce food waste. By suppressing the gene responsible for browning, the new banana stays fresher for longer, both on shelves and in homes. This extended shelf-life aims to reduce the substantial amount of bananas wasted due to cosmetic browning, making the fruit more appealing to consumers and retailers for a longer period. Field trials are planned in the US, although the genetically modified nature of the fruit may face regulatory hurdles and consumer resistance in some markets.
DARPA's BioManufacturing in Space program seeks to leverage the unique microgravity environment of space to grow large, complex biostructures currently impossible to produce on Earth. This research aims to overcome terrestrial limitations like gravity-induced stresses and nutrient transport challenges. The program will explore new biomanufacturing techniques and evaluate the feasibility of producing these structures in orbit, with potential applications including tissue engineering, organ fabrication, and advanced materials development for defense and commercial sectors.
HN commenters express skepticism about the feasibility and practicality of DARPA's proposal to grow large biological structures in space. Several doubt the cost-effectiveness compared to Earth-based manufacturing, citing the expense of launching and maintaining such a complex system in orbit. Others question the specific advantages of microgravity for this purpose, suggesting alternative solutions like scaffolding or 3D bioprinting on Earth. Some raise concerns about potential biohazards and the ethical implications of creating large, novel biological structures. A few highlight the potential for scientific discovery and acknowledge the innovative nature of the project, albeit with reservations about its ultimate success. Several users also note the military context of DARPA's involvement, speculating about potential applications in areas like bioweapons or self-repairing spacecraft.
This project details modifications to a 7500 Fast Real-Time PCR System to enable independent verification of its operation. By replacing the embedded computer with a Raspberry Pi and custom software, the project aims to achieve full control over the thermocycling process and data acquisition, eliminating reliance on proprietary software and potentially increasing experimental transparency and reproducibility. The modifications include custom firmware, a PCB for interfacing with the thermal block and optical system, and open-source software for experiment design, control, and data analysis. The goal is to create a completely open-source real-time PCR platform.
HN commenters discuss the feasibility and implications of a modified PCR machine capable of verifying scientific papers. Several express skepticism about the practicality of distributing such a device widely, citing cost and maintenance as significant hurdles. Others question the scope of verifiability, arguing that many scientific papers rely on more than just PCR and thus wouldn't be fully validated by this machine. Some commenters suggest alternative approaches to improving scientific reproducibility, such as better data sharing and standardized protocols. A few express interest in the project, seeing it as a potential step towards more transparent and trustworthy science, particularly in fields susceptible to fraud or manipulation. There is also discussion on the difficulty of replicating wet lab experiments in general, highlighting the complex, often undocumented nuances that can influence results. The creator's focus on PCR is questioned, with some suggesting other scientific methods might be more impactful starting points for verification.
Researchers at the Walter and Eliza Hall Institute have developed a promising new experimental cancer treatment using modified CAR T cells. Pre-clinical testing in mice showed the treatment successfully eliminated solid tumors and prevented their recurrence without the severe side effects typically associated with CAR T cell therapy. This breakthrough paves the way for human clinical trials, offering potential hope for a safer and more effective treatment option against solid cancers.
HN commenters express cautious optimism about the pre-clinical trial results of a new cancer treatment targeting the MCL-1 protein. Several highlight the difficulty of translating promising pre-clinical findings into effective human therapies, citing the complex and often unpredictable nature of cancer. Some question the specificity of the treatment and its potential for side effects given MCL-1's role in healthy cells. Others discuss the funding and development process for new cancer drugs, emphasizing the lengthy and expensive road to clinical trials and eventual approval. A few commenters share personal experiences with cancer and express hope for new treatment options. Overall, the sentiment is one of tempered excitement, acknowledging the early stage of the research while recognizing the potential significance of the findings.
DARPA is seeking innovative research proposals for the development of large, adaptable bio-mechanical structures for use in space. The goal is to leverage biological systems like plant growth or fungal mycelia to create structures in orbit, reducing the reliance on traditional manufacturing and launch limitations. This research will focus on demonstrating the feasibility of bio-based structural materials that can self-assemble, self-repair, and adapt to changing mission needs in the harsh space environment. The program envisions structures potentially spanning kilometers in size, drastically changing the possibilities for space-based habitats, solar sails, and other large systems.
Hacker News users discuss the feasibility and practicality of DARPA's bio-engineered space structure concept. Several express skepticism about the project's timeline and the biological challenges involved, questioning the maturity of the underlying science and the ability to scale such a project within the proposed budget and timeframe. Some highlight the potential benefits of using biological systems for space construction, such as self-repair and adaptability, while others suggest focusing on more established materials science approaches. The discussion also touches upon the ethical implications of introducing engineered life forms into space and the potential for unintended consequences. A few commenters note the ambitious nature of the project and the possibility that it serves primarily as a stimulus for research and development in related fields.
Researchers engineered 42 complex human cell lines with extensive structural variations in their genomes, including inversions, deletions, and duplications, to study the impact on cell viability and function. Surprisingly, they found that cells tolerated a wide range of these large-scale genomic alterations with minimal effects on gene expression or growth. This suggests human genomes are remarkably resilient to structural changes, challenging the conventional understanding of their fragility and offering insights into cancer development, evolution, and potential therapeutic strategies.
HN commenters discussed the implications of the study's findings, with some expressing skepticism about the robustness of the engineered cell lines. One commenter questioned whether the rearranged chromosomes would affect gene regulation in subtle, yet significant, ways that weren't captured in the initial analysis. Another pointed out the importance of long-term studies to observe potential downstream effects, such as an increased risk of cancer or other diseases. Several commenters also highlighted the ethical considerations of large-scale genome engineering in humans, even for therapeutic purposes, urging caution and further research before any clinical applications are considered. A few commenters expressed excitement about the potential of this research to advance our understanding of genome organization and its role in disease, while also acknowledging the significant challenges that remain.
Rwandan scientists have developed a specific yeast strain optimized for fermenting banana wine, addressing inconsistent quality and improving the efficiency of traditional brewing methods. This locally sourced yeast offers winemakers greater control over the fermentation process, leading to a more predictable and higher quality product. This innovation could boost the banana wine industry in Rwanda, supporting local producers and potentially opening up new market opportunities.
HN commenters generally expressed enthusiasm for the Rwandan scientists' work developing local yeast strains for banana wine. Several praised the focus on local resources and the potential for economic development within Rwanda. Some discussed the sensory implications of different yeast strains, noting the potential for unique flavor profiles. Others highlighted the broader implications for scientific advancement in Africa, contrasting it with a perceived Western-centric focus in much research. A few commenters raised questions about scalability and the regulatory hurdles involved in introducing new yeast strains for food production. A couple of users shared personal anecdotes related to banana wine and brewing.
Caltech researchers have engineered a new method for creating "living materials" by embedding bacteria within a polymer matrix. These bacteria produce amyloid protein nanofibers that intertwine, forming cable-like structures that extend outward. As these cables grow, they knit the surrounding polymer into a cohesive, self-assembling gel. This process, inspired by the way human cells build tissues, enables the creation of dynamic, adaptable materials with potential applications in biomanufacturing, bioremediation, and regenerative medicine. These living gels could potentially be used to produce valuable chemicals, remove pollutants from the environment, or even repair damaged tissues.
HN commenters express both excitement and caution regarding the potential of the "living gels." Several highlight the potential applications in bioremediation, specifically cleaning up oil spills, and regenerative medicine, particularly in creating new biomaterials for implants and wound healing. Some discuss the impressive self-assembling nature of the bacteria and the possibilities for programmable bio-construction. However, others raise concerns about the potential dangers of such technology, wondering about the possibility of uncontrolled growth and unforeseen ecological consequences. A few commenters delve into the specifics of the research, questioning the scalability and cost-effectiveness of the process, and the long-term stability of the gels. There's also discussion about the definition of "life" in this context, and the implications of creating and controlling such systems.
Summary of Comments ( 21 )
https://news.ycombinator.com/item?id=43299772
HN commenters discuss the potential benefits of the non-browning banana for reducing food waste, especially at the retail level. Some express skepticism about whether browning is the primary reason for banana waste, suggesting other factors like overripe fruit and bruising are more significant. Others question the actual impact on waste given the existing infrastructure for banana processing into other products like banana bread. A few commenters raise concerns about public acceptance of GMOs and the potential for unforeseen consequences of genetic modification. There's also discussion about alternative approaches to reducing food waste, like improved supply chain management and consumer education. Finally, several comments mention Cavendish monoculture's susceptibility to disease and the hope that gene editing can contribute to developing more resilient varieties.
The Hacker News post "Gene-edited non-browning banana could cut food waste" generated several comments discussing various aspects of the gene-edited banana and its potential impact.
Several commenters focused on the practicality and effectiveness of the modification. Some questioned whether browning is the primary reason for banana waste, suggesting other factors like overripening or bruising might be more significant. One commenter highlighted the potential benefits for retailers, as the extended shelf life could reduce losses. Another wondered about the consumer acceptance of genetically modified produce, pointing out that appearance often drives purchasing decisions.
The discussion also touched upon the broader implications of gene editing technology. One commenter raised concerns about the potential for unintended consequences of genetic modification, while another countered by arguing that traditional breeding methods also alter genes, just less precisely. The ethical considerations surrounding gene editing were also mentioned, with one commenter suggesting that resources might be better allocated to addressing food waste through improved logistics and education.
A few comments delved into the scientific aspects of the gene editing process. One user inquired about the specific gene targeted and the mechanism by which browning is prevented. Another questioned the long-term stability of the genetic modification and whether it would be maintained through successive generations of banana plants.
Finally, some comments focused on the article itself. One commenter criticized The Guardian for its perceived bias against genetic modification, suggesting the article's framing was overly negative. Another appreciated the article's balanced approach, noting that it presented both the potential benefits and the concerns surrounding the technology. One user simply expressed disappointment that the article didn't include a picture of the non-browning banana.