23andMe offers two data deletion options. "Account Closure" removes your profile and reports, disconnects you from DNA relatives, and prevents further participation in research. However, de-identified genetic data may be retained for internal research unless you specifically opt out. "Spit Kit Destruction" goes further, requiring contacting customer support to have your physical sample destroyed. While 23andMe claims anonymized data may still be used, they assert it can no longer be linked back to you. For the most comprehensive data removal, pursue both Account Closure and Spit Kit Destruction.
23andMe has filed for bankruptcy and CEO Anne Wojcicki has resigned. Facing declining demand for at-home DNA testing kits and a challenging market for drug development, the company struggled to turn a profit. The bankruptcy filing allows 23andMe to restructure its finances and potentially sell off assets, while Wojcicki's departure marks the end of her leadership at the company she co-founded.
Hacker News users reacted to 23andMe's bankruptcy announcement with skepticism, quickly identifying the article as satire published on April 1st. Several commenters expressed initial surprise before recognizing the date, while others pointed out the unrealistic nature of the claims, such as selling user data to CVS. Some found the satire weak, suggesting it wasn't particularly funny or clever. A few users discussed the actual business model of 23andMe, highlighting the shift from ancestry information to pharmaceutical research leveraging user data. One commenter noted the irony of the fictional bankruptcy coming shortly after 23andMe's actual recent layoffs.
A new study reveals a shared mechanism for coping with environmental stress in plants and green algae dating back 600 million years to their common ancestor. Researchers found that both plants and algae utilize a protein called CONSTANS, originally known for its role in flowering, to manage responses to various stresses like drought and high salinity. This ancient stress response system involves CONSTANS interacting with other proteins to regulate gene expression, protecting the organism from damage. This discovery highlights a highly conserved and essential survival mechanism across the plant kingdom and offers potential insights into improving stress tolerance in crops.
HN commenters discuss the implications of the study showing a shared stress response across algae and plants, questioning whether this truly represents 600 million years of conservation or if horizontal gene transfer played a role. Some highlight the importance of understanding these mechanisms for improving crop resilience in the face of climate change. Others express skepticism about the specific timeline presented, suggesting further research is needed to solidify the evolutionary narrative. The potential for biotechnological applications, such as engineering stress tolerance in crops, is also a point of interest. A few users dive into the specifics of the abscisic acid (ABA) pathway discussed in the study, pointing out its known role in stress response and questioning the novelty of the findings. Overall, the comments demonstrate a mix of intrigue, cautious interpretation, and a focus on the practical implications for agriculture and biotechnology.
A new genomic study suggests that the human capacity for language originated much earlier than previously thought, at least 135,000 years ago. By analyzing genomic data from diverse human populations, researchers identified specific gene variations linked to language abilities that are shared across these groups. This shared genetic foundation indicates a common ancestor who possessed these language-related genes, pushing back the estimated timeline for language emergence significantly. The study challenges existing theories and offers a deeper understanding of the evolutionary history of human communication.
Hacker News users discussed the study linking genomic changes to language development 135,000 years ago with some skepticism. Several commenters questioned the methodology and conclusions, pointing out the difficulty in definitively connecting genetics to complex behaviors like language. The reliance on correlating genomic changes in modern humans with archaic human genomes was seen as a potential weakness. Some users highlighted the lack of fossil evidence directly supporting language use at that time. Others debated alternative theories of language evolution, including the potential role of FOXP2 variants beyond those mentioned in the study. The overall sentiment was one of cautious interest, with many acknowledging the limitations of current research while appreciating the attempt to explore the origins of language. A few also expressed concern about the potential for misinterpreting or overhyping such preliminary findings.
Scientists have successfully extracted ancient human DNA from a deer tooth pendant found in Denisova Cave, Siberia, dating back to the Upper Palaeolithic period (19,000-25,000 years ago). By using a novel method that extracts DNA from the artifact's pores without damaging it, they recovered DNA from a woman genetically related to ancient North Eurasians. This breakthrough demonstrates the potential of porous materials like bone and teeth artifacts to preserve DNA and opens up new avenues for studying ancient human populations and their interactions with cultural objects. It suggests that handling such artifacts leaves detectable DNA and may help shed light on their creation, use, and ownership within past societies.
Hacker News users discussed the implications of recovering ancient human DNA from a 25,000-year-old pendant, focusing on the potential of this method for future discoveries. Some expressed skepticism about contamination, questioning how the DNA survived so long in a porous material. Others highlighted the significance of retrieving DNA from handled objects, opening possibilities for understanding social structures and individual interactions with artifacts. The innovative technique used to extract the DNA without destroying the pendant was also praised, and several users speculated about the stories this discovery could tell about the pendant's owner and their life. The ethical implications of handling such artifacts were briefly touched upon. Several commenters also compared the methodology and findings to similar research involving ancient chewing gum.
Research on Syrian refugees suggests that exposure to extreme violence can cause epigenetic changes, specifically alterations to gene expression rather than the genes themselves, that can be passed down for at least two generations. The study found grandsons of men exposed to severe violence in the Syrian conflict showed altered stress hormone regulation, even though these grandsons never experienced the violence firsthand. This suggests trauma can have lasting biological consequences across generations through epigenetic inheritance.
HN commenters were skeptical of the study's methodology and conclusions. Several questioned the small sample size and the lack of control for other factors that might influence gene expression. They also expressed concerns about the broad interpretation of "violence" and the potential for oversimplification of complex social and biological interactions. Some commenters pointed to the difficulty of isolating the effects of trauma from other environmental and genetic influences, while others questioned the study's potential for misinterpretation and misuse in justifying discriminatory policies. A few suggested further research with larger and more diverse populations would be needed to validate the findings. Several commenters also discussed the ethics and implications of studying epigenetics in conflict zones.
Genetic analysis of killer whale scat collected around the Bremer Bay region of Australia confirms predation on white sharks. Researchers identified white shark DNA in multiple samples, including muscle and skin tissue. This provides direct dietary evidence supporting anecdotal observations of killer whale predation on white sharks in the area, including targeted attacks on the sharks' livers, a nutrient-rich organ. The study highlights the ecological role of killer whales as apex predators and their potential impact on white shark populations.
HN commenters discuss the methodology and implications of the study. Some question the small sample size (4 sharks with orca DNA) and suggest alternative explanations for the orca DNA presence, such as scavenging or secondary transfer. Others highlight the observed behavioral shift in white sharks avoiding areas where orcas are present, suggesting learned predator avoidance despite limited direct predation evidence. The discussion also touches on the ecological impact of apex predator interactions and the cascading effects on the ecosystem. Some express fascination with the topic and share anecdotal evidence or similar observations in other regions.
A new study combining ancient DNA analysis with linguistic and archaeological data suggests the Indo-European language family originated with the Yamnaya pastoralists who migrated from the Pontic-Caspian steppe into Europe around 5,000 years ago. These migrations, associated with the spread of wheeled vehicles and early horse domestication, brought the Yamnaya into contact with European hunter-gatherers, resulting in a genetic admixture that ultimately led to the Corded Ware culture. This Corded Ware population is identified as the source of later migrations eastward, spreading Indo-European languages across Europe and Asia.
Hacker News users discussed the methodology and implications of the study. Several commenters questioned the reliability of inferring large-scale migrations and cultural shifts solely from genetic data, emphasizing the complexity of language evolution and its potential disconnect from genetic lineages. Some pointed to known instances of language replacement without significant population change, highlighting the limitations of using genetics as the sole indicator. Others debated the specific migration routes proposed in the study and alternative theories regarding the spread of Indo-European languages. The discussion also touched on the sensitivity surrounding research into ancient populations and the importance of respectful and accurate interpretation of findings. Some users expressed concern about potential misuse of such research to support nationalist narratives.
The essay "In Praise of Subspecies" argues for the renewed recognition and utilization of the subspecies classification in conservation efforts. The author contends that while the concept of subspecies has fallen out of favor due to perceived subjectivity and association with outdated racial theories, it remains a valuable tool for identifying and protecting distinct evolutionary lineages within species. Ignoring subspecies risks overlooking significant biodiversity and hindering effective conservation strategies. By acknowledging and protecting subspecies, we can better safeguard evolutionary potential and preserve the full richness of life on Earth.
HN commenters largely discussed the complexities and ambiguities surrounding the subspecies classification, questioning its scientific rigor and practical applications. Some highlighted the arbitrary nature of defining subspecies based on often slight morphological differences, influenced by historical biases. Others pointed out the difficulty in applying the concept to microorganisms or species with clinal variation. The conservation implications were also debated, with some arguing subspecies classifications can hinder conservation efforts by creating artificial barriers and others suggesting they can be crucial for preserving unique evolutionary lineages. Several comments referenced the "species problem" and the inherent challenge in categorizing biological diversity. A few users mentioned specific examples, like the red wolf and the difficulties faced in its conservation due to subspecies debates.
During the 900-day siege of Leningrad in World War II, the Vavilov Institute, home to a vast collection of seeds and plant material, became a poignant symbol of resistance and sacrifice. Facing starvation, the scientists working there protected the invaluable collection, even choosing to die of hunger rather than consume the edible seeds and tubers under their care. This act of extraordinary dedication preserved crucial biodiversity for future generations, highlighting the enduring power of scientific commitment amidst unimaginable hardship. The article explores this story, emphasizing the difficult ethical decisions faced by the scientists and the lasting legacy of Nikolai Vavilov, the Institute's founder who perished in a Stalinist prison.
HN commenters largely focused on the astounding dedication of Vavilov and his team of scientists. Several highlighted the irony of researchers starving to death amidst a seed bank containing the potential to alleviate global hunger. Some debated the practicality of seed saving in a besieged city, questioning if distributing the food would have been a better short-term solution. Others drew parallels to contemporary seed banks like the Svalbard Global Seed Vault, emphasizing the importance of preserving biodiversity. A few comments offered additional historical context about Lysenko and his detrimental impact on Soviet agriculture, or about other sieges where similar acts of sacrifice occurred. Several commenters expressed gratitude for the article, finding it both informative and moving.
The "Third Base" article explores the complex role of guanine quadruplexes (G4s), four-stranded DNA structures, in biology. Initially dismissed as lab artifacts, G4s are now recognized as potentially crucial elements in cellular processes. They are found in telomeres and promoter regions of genes, suggesting roles in aging and gene expression. The article highlights the dynamic nature of G4 formation and how it can be influenced by proteins and small molecules. While research is ongoing, G4s are implicated in both vital functions and diseases like cancer, raising the possibility of targeting them for therapeutic interventions.
Hacker News users discuss the surprisingly complex history and evolution of third base in baseball. Several commenters highlight the article's insightful explanation of how the base's positioning has changed over time, influenced by factors like foul territory rules and the gradual shift from a "bound catch" rule to the modern fly catch. Some express fascination with the now-obsolete "three strikes and you're out if it's caught on the first bounce" rule. Others appreciate the detailed descriptions of early baseball and how the different rules shaped the way the game was played. A few commenters draw parallels between the evolution of baseball and the development of other sports and games, emphasizing how seemingly arbitrary rules can have significant impacts on strategy and gameplay. There is general appreciation for the depth of research and clear writing style of the article.
Summary of Comments ( 5 )
https://news.ycombinator.com/item?id=43486236
HN commenters largely discuss the complexities of truly deleting genetic data. Several express skepticism that 23andMe or similar services can fully remove data, citing research collaborations, anonymized datasets, and the potential for data reconstruction. Some suggest more radical approaches like requesting physical sample destruction, while others debate the ethical implications of research using genetic data and the individual's right to control it. The difficulty of separating individual data from aggregated research sets is a recurring theme, with users acknowledging the potential benefits of research while still desiring greater control over their personal information. A few commenters also mention the potential for law enforcement access to such data and the implications for privacy.
The Hacker News post "How to Delete Your 23andMe Data" has a moderate number of comments, discussing various aspects of genetic data privacy and the complexities of truly deleting such sensitive information.
Several commenters express skepticism about the efficacy of 23andMe's deletion process, pointing out that true deletion of data is difficult, especially when it has potentially been used in aggregate analyses or shared with research partners. One commenter highlights the distinction between "individual data" and "aggregate data," suggesting that while 23andMe might remove individual identifiers, the underlying genetic information might still be retained and used in broader studies. This leads to a discussion about the inherent value of genetic data for research, and the ethical considerations surrounding its use.
Some comments also mention the potential legal implications of data retention, particularly in light of law enforcement requests. One user points out that even if 23andMe deletes the data, they may still be compelled to provide it if legally required. This raises concerns about the security and privacy of genetic information, even after a user requests its deletion.
A few commenters share their personal experiences with 23andMe's data deletion process, with varying degrees of satisfaction. Some report a smooth and straightforward experience, while others express frustration with the complexity or lack of clarity in the process.
The conversation also touches upon the broader issue of data ownership and control in the digital age. One comment questions whether individuals truly "own" their genetic data, given the complexities of data sharing and analysis within the scientific and commercial landscape. This leads to a discussion about the need for clearer regulations and greater transparency regarding the use of personal data, particularly sensitive information like genetic data.
Finally, some commenters mention alternative genetic testing services and their data privacy policies, offering a comparative perspective on how different companies handle user data. This provides a practical element to the discussion, allowing users to consider various options based on their individual privacy preferences.